|
KMID : 0376219820190010091
|
|
Chonnam Medical Journal
1982 Volume.19 No. 1 p.91 ~ p.98
|
|
|
Hyperglycemia-inducing mechanism of rodenticide Vacor(RH-787)
|
|
|
|
|
Abstract
|
|
|
It is now well established that the rodenticide Vacor(RH-787, N-3-pyridylmethyl-N´-p-nitrophenylurea) causes a hyperglycemia in man and its accidental ingestion leads to the development of a permanent diabetes mellitus. In 1979, we reported that unlike usual diabetes mellitus, Vacor-poisoned patients with hyperglycemia have normal plasma insulin levels, and suggested that Vacor may interfere with the peripheral tissue responsiveness to insulin.
In the present study, the effects of Vacor on insulin and amylase secretion stimulated by glucose and caerulein were studied in isolated perfuse pancreas of Wistar rats. In addition, to clarify the involvement of any extrapancreatic factor(s) in the development of Vacor-induced hyperglycemia, the effect of Vacor on the metabolic response of peripheral tissues to insulin was studied in isolated rat adipocytes.
The results were obtained as follows:
1. The Vacor-poisoned pancreas isolated from rats 5 hours after Vacor ingestion showed the same biphasic insulin secretion phases after glucose stimulation as in the normal control ones. Although the Vacor-poisoning induced a slight reduction in glucose-stimulated insulin output both in the early and late secretion phases, it was not statistically significant.
2. The Vacor-poisoning caused an increase in amylase basal output. However, the Vacor-poisoning caused a significant depression in the caerulein-stimulated amylase output, while the pancreatic exocrine flow rates were not affected byVacor.
3, Insulin added in vitro to.the adipocytes of normal rat epididymal Xdi tissue caused an increase in the conversion of glucose carbon 1 to CO2 and lipid. Vacor added in vitro significantly reduced these metabolic responses to insulin of normal rat adipocytes.
These results indicate that while Vacor partially disturbs the pancreatic exocrine function, it does not exert any significant influence on insulin secretion from the pancreas. The reduced response of adipocytes to insulin in the presence of Vacor suggests that such an extrapancreatic effect of Vacor may lead to hyperglycemia even in the presence of insulin.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|